| Tumor Endothelial Marker 5 | OKDB#: 1786 |
| Symbols: | GPR124 | Species: | human | ||
| Synonyms: | TEM5,FLJ14390, KIAA1531, DKFZp434C211, DKFZp434J0911,TEM5 | Locus: | 8p12 in Homo sapiens | HPMR |
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| General Comment |
Using serial analysis of gene expression (SAGE), St Croix et al. (2000) identified partial cDNAs corresponding to several tumor endothelial markers (TEMs) that displayed elevated expression during tumor angiogenesis. Among the genes they identified was TEM5. TEM5 encodes a predicted 7-pass transmembrane protein of 1,331 amino acids. The N-terminal extracellular region contains 4 simple leucine-rich repeats (LRRs), a C-terminal LRR, an immunoglobulin-type domain, a hormone receptor domain, and a putative G protein-coupled receptor (GPCR) proteolysis site domain typical of class II family members and required for endogenous proteolysis. TEM5 is expressed in the corpus luteum.
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| General function | Receptor | ||||
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| Cellular localization | Plasma membrane | ||||
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| Ovarian function | Luteinization | ||||
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| Expression regulated by | |||||
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| Ovarian localization | Luteal cells | ||||
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| Follicle stages | Corpus luteum | ||||
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| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | April 23, 2003, 1:11 p.m. | by: |
hsueh email:
home page: |
| last update: | July 2, 2007, 4:21 p.m. | by: | rami email: |
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