| LYMPHOID ENHANCER-BINDING FACTOR 1; LEF1 | OKDB#: 1794 |
| Symbols: | LYMPHOID ENHANCER-BINDING FACTOR 1; LEF1 | Species: | human | ||
| Synonyms: | TRANSCRIPTION FACTOR, T CELL-SPECIFIC, 1-ALPHA| TCF1-ALPHA| | Locus: | 4q23-q25 in Homo sapiens |
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For retrieval of Nucleotide and Amino Acid sequences please go to:
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Entrez Gene
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| General Comment |
Lymphoid enhancer-binding factor-1 (LEF1) is a 48-kD nuclear protein that is expressed in pre-B and T cells. It binds to a functionally important site in the T-cell receptor-alpha (TCRA; OMIM 186880) enhancer and confers maximal enhancer activity. LEF1 belongs to a family of regulatory proteins that share homology with high mobility group protein-1 (HMG1;OMIM 163905).
NCBI Summary: Lymphoid enhancer-binding factor-1 (LEF1) is a 48-kD nuclear protein that is expressed in pre-B and T cells. It binds to a functionally important site in the T-cell receptor-alpha (TCRA; MIM 186880) enhancer and confers maximal enhancer activity. LEF1 belongs to a family of regulatory proteins that share homology with high mobility group protein-1 (HMG1; MIM 163905).[supplied by OMIM] |
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| General function | DNA binding, Transcription factor | ||||
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| Cellular localization | Nuclear | ||||
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| Ovarian function | Follicle development | ||||
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| Expression regulated by | |||||
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| Ovarian localization | Granulosa | ||||
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| Follicle stages | Antral | ||||
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| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | May 7, 2003, 1:26 p.m. | by: |
hsueh email:
home page: |
| last update: | May 7, 2003, 1:26 p.m. | by: | system email: |
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