| Low Density Lipoprotein Receptor-related Protein 6 | OKDB#: 1798 |
| Symbols: | LRP6 | Species: | human | ||
| Synonyms: | Locus: | 12p13.3-p11.2 in Homo sapiens | HPMR |
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| General Comment |
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDLR proteins are comprised of the same basic structural motifs: an extracellular domain which contains LDLR binding repeats, and EGF repeats with associated spacer domains containing the YWTD motif; a single transmembrane-spanning domain; and a C-terminal cytoplasmic domain which generally contains at least 1 copy of the NPXY motif. LRP6 was isolated based on sequence homology to LDLR.
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| General function | Receptor | ||||
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| Cellular localization | Plasma membrane | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | May 7, 2003, 6:06 p.m. | by: |
hsueh email:
home page: |
| last update: | Nov. 5, 2003, 1:46 p.m. | by: | system email: |
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