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HPMR

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176557

Low Density Lipoprotein Receptor-related Protein 6 OKDB#: 1798
 Symbols: LRP6 Species: human
 Synonyms:  Locus: 12p13.3-p11.2 in Homo sapiens
HPMR


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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General Comment The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDLR proteins are comprised of the same basic structural motifs: an extracellular domain which contains LDLR binding repeats, and EGF repeats with associated spacer domains containing the YWTD motif; a single transmembrane-spanning domain; and a C-terminal cytoplasmic domain which generally contains at least 1 copy of the NPXY motif. LRP6 was isolated based on sequence homology to LDLR.

General function Receptor
Comment
Cellular localization Plasma membrane
Comment
Ovarian function
Comment
Expression regulated by
Comment
Ovarian localization
Comment
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
OMIM \ Animal Model
KEGG Pathways
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created: May 7, 2003, 6:06 p.m. by: hsueh   email:
home page:
last update: Nov. 5, 2003, 1:46 p.m. by: system    email:



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