| HSDL2, hydroxysteroid dehydrogenase like 2 | OKDB#: 1905 |
| Symbols: | HSDL2, hydroxysteroid dehydrogenase like 2 | Species: | human | ||
| Synonyms: | Locus: |
|
For retrieval of Nucleotide and Amino Acid sequences please go to:
UCSC Genome Browser
GEO Profiles
new!
Amazonia (transcriptome data)
new!
R-L INTERACTIONS MGI |
| General Comment |
Dai et al reported mMolecular cloning and characterization of a novel human hydroxysteroid
dehydrogenase-like 2 (HSDL2) cDNA from fetal brain.
Hydroxysteroid dehydrogenases (HSDs) are responsible for the biosynthesis of steroid hormones
and play a crucial role in mammalian physiology and development. By large-scale sequencing
analysis of a human fetal brain cDNA library, the authors isolated a novel human hydroxysteroid
dehydrogenase-like cDNA (HSDL2). This cDNA is 3211 bp in length, encoding a 418-amino-acid
polypeptide, which contains a typical motif for NAD(P)+-binding (TGxxxGxG), an SDR active site
motif (S-Y-K) and a sterol carrier protein domain. HSDL2 shows high similarity with the
homologues in the mouse and fruit fly. The HSDL2 gene is mapped to chromosome 9q32 and
contains 11 exons. RT-PCR analysis shows that the HSDL2 gene is widely expressed in human
tissues and the expression levels in liver, kidney, prostate, testis, and ovary are relatively high.
|
|||
| General function | Enzyme | |||
| Comment | ||||
| Cellular localization | Cytoplasmic | |||
| Comment | ||||
| Ovarian function | Steroid metabolism | |||
| Comment | ||||
| Expression regulated by | ||||
| Comment | ||||
| Ovarian localization | ||||
| Comment | ||||
| Follicle stages | ||||
| Comment | ||||
| Phenotypes | ||||
| Mutations | 0 mutations | |||
| Genomic Region | show genomic region | |||
| Phenotypes and GWAS | show phenotypes and GWAS | |||
| Links |
|
| created: | July 9, 2003, 9:41 a.m. | by: |
hsueh email:
home page: |
| last update: | July 9, 2003, 9:41 a.m. | by: | system email: |
Click here to return to gene search form