NCBI Summary:
Calcyon is a type II single transmembrane protein. It is required for maximal stimulated calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors. Interacts with D1 dopamine receptor and may interact with other DA receptor subtypes and/or GPCRs.
General function
Receptor
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Cellular localization
Plasma membrane
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Ovarian function
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Expression regulated by
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Ovarian localization
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Calcyon was recently identified as a D1 dopamine receptor (DR1) interacting protein. Previous
studies show that calcyon can potentiate DR1 mediated intracellular Ca(2+) release in transfected
HEK293 cells, and may play an important role in DR1 Ca(2+) signaling in brain. Dai et al report that
similar to the genomic structure of the human gene, the mouse calcyon gene contains six relatively
short exons, with a large intron (about 8.4 kb) between exons one and two. The mouse and human
calcyon genes exhibit a high level of sequence homology (77.5% at the nucleotide level) within
coding regions. Northern blot and RT-PCR analyses reveal that mouse calcyon transcripts are most abundant in brain, but also present in testis and ovary, as well as in kidney and heart at much lower
levels.