Silenced expression of the FMR1 gene (309550) is responsible for fragile X syndrome. The FMR1 gene encodes an RNA-binding protein (FMRP) that can shuttle between the nucleus and the cytoplasm and is found associated with polysomes in the cytoplasm. Using a yeast 2-hybrid assay, Bardoni et al. (1999) identified a novel protein interacting with FMRP, and they designated the protein NUFIP (nuclear FMRP-interacting protein). NUFIP mRNA expression was found to be strikingly similar to that of the FMR1 gene in neurons of cortex, and cerebellum. At the subcellular level, NUFIP colocalized with nuclear isoforms of FMRP in a dot-like pattern. NUFIP contains a C2H2 zinc finger motif and a nuclear localization signal. In vitro, NUFIP showed RNA-binding activity.
General function
Cell proliferation, RNA processing, RNA binding
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Cellular localization
Nuclear
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Ovarian function
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Expression regulated by
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Ovarian localization
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This gene was found in a PMSG-treated ovarina library.