NCBI Summary:
The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction.
General function
Receptor
Comment
Cellular localization
Plasma membrane
Comment
Ovarian function
Comment
Expression regulated by
Comment
Ovarian localization
Oocyte, Granulosa
Comment
Salmassi A, et al. (2004) reported that granulocyte colony-stimulating factor and its receptor were expressed by GCs, which was detected by immunostaining.
Conditional deletion of the colony stimulating factor-1 receptor (c-fms proto-oncogene) in mice. Li J et al. Colony stimulating factor-1 (CSF-1) is the primary regulator of the mononuclear phagocytic lineage acting through its transmembrane tyrosine kinase receptor, CSF-1R, that is the product of the c-fms proto-oncogene. Null mutations in either the ligand or the receptor genes result in a severe osteopetrosis as well as a number of other phenotypes, including reproductive defects and perturbations in organ development. The CSF-1R is also expressed in oocytes, myoblast progenitors, decidual, and trophoblastic cells. To distinguish cell type specific phenotypes, we have created a conditional allele of the Csf1r by placing LoxP sites around Exon 5 of the Csf1r gene in mice. Excision of this floxed sequence results in a null allele that in the homozygous state gives a phenotype indistinguishable of the complete Csf1r null mutant mouse. This conditional allele will prove extremely valuable to study the spatial and temporal roles of CSF-1R. genesis 44:328-335, 2006. (c) 2006 Wiley-Liss, Inc.
Follicle stages
Comment
This gene was found in a mouse DNA array analysis of transcripts expressed in mouse preovulatory follicles.