| Integrin, Alpha-3 | OKDB#: 2179 |
| Symbols: | ITGA3 | Species: | human | ||
| Synonyms: | CD49C|VERY LATE ACTIVATION PROTEIN 3 RECEPTOR, ALPHA-3 SUBUNIT|GALACTOPROTEIN B3, GAPB3 | Locus: | 17 in Homo sapiens | HPMR |
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| General Comment | NCBI Summary: ITGA3 encodes the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular-matrix proteins. The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 ('VLA-3'), very common antigen 2 ('VCA-2'), extracellular matrix receptor 1 ('ECMR1'), and galactoprotein b3 ('GAPB3'). | ||||
| General function | Receptor | ||||
| Comment | |||||
| Cellular localization | Plasma membrane | ||||
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| Ovarian function | |||||
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| Expression regulated by | |||||
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| Ovarian localization | |||||
| Comment | This gene was found in a mouse DNA array analysis of transcripts expressed in mouse preovulatory follicles. | ||||
| Follicle stages | |||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | Oct. 14, 2003, 10:24 a.m. | by: |
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| last update: | May 2, 2004, 8:50 a.m. | by: | system email: |
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