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Ovarian Kaleidoscope Database (OKdb)

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HPMR

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176557

interleukin 17 receptor C OKDB#: 2262
 Symbols: IL17RC Species: human
 Synonyms: IL17RL, IL17-RL, FLJ95963, FLJ96005, MGC10763,INTERLEUKIN 17 RECEPTOR HOMOLOG 1, IL17RH1|  Locus: 3p25.3 in Homo sapiens
HPMR


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General Comment NCBI Summary: This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]
General function Receptor
Comment
Cellular localization Plasma membrane
Comment
Ovarian function
Comment
Expression regulated by
Comment
Ovarian localization
Comment
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
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created: Nov. 10, 2003, noon by: xin   email:
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last update: May 2, 2012, 1 p.m. by: hsueh    email:



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