| interleukin 17 receptor A | OKDB#: 2263 |
| Symbols: | IL17RA | Species: | human | ||
| Synonyms: | CD217, IL17R, CANDF5, CDw217, IL-17RA, hIL-17R | Locus: | 22q11.1 in Homo sapiens | HPMR |
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| General Comment |
This gene was found through a mouse ovarian follicle microarray.
NCBI Summary: Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014] |
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| General function | Receptor | ||||
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| Cellular localization | Plasma membrane | ||||
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| Ovarian function | |||||
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| Expression regulated by | |||||
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| Ovarian localization | Granulosa | ||||
| Comment | FOund in ORG array | ||||
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| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | Nov. 10, 2003, 12:01 p.m. | by: |
xin email:
home page: |
| last update: | Feb. 5, 2016, 9:39 a.m. | by: | hsueh email: |
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