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HPMR

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176557

interleukin 17 receptor A OKDB#: 2263
 Symbols: IL17RA Species: human
 Synonyms: CD217, IL17R, CANDF5, CDw217, IL-17RA, hIL-17R  Locus: 22q11.1 in Homo sapiens
HPMR


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General Comment This gene was found through a mouse ovarian follicle microarray.

NCBI Summary: Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]
General function Receptor
Comment
Cellular localization Plasma membrane
Comment
Ovarian function
Comment
Expression regulated by
Comment
Ovarian localization Granulosa
Comment FOund in ORG array
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
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created: Nov. 10, 2003, 12:01 p.m. by: xin   email:
home page:
last update: Feb. 5, 2016, 9:39 a.m. by: hsueh    email:



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