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Ovarian Kaleidoscope Database (OKdb)

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Neuromedin B Receptor OKDB#: 2289
 Symbols: NMBR Species: human
 Synonyms: CMKBR1| CKR1| MACROPHAGE INFLAMMATORY PROTEIN 1-ALPHA/RANTES RECEPTOR| HM145|  Locus: 6q21-qter in Homo sapiens
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For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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General Comment NCBI Summary: Neuromedin B receptor binds neuromedin B, a potent mitogen and growth factor for normal and neoplastic lung and for gastrointestinal epithelial tissue.
General function Receptor
Comment
Cellular localization Plasma membrane
Comment
Ovarian function Oogenesis, Oocyte maturation
Comment Genes whose expression is detected by cDNA array hybridization: cell surface antigens, cell adhesion, receptors Rozenn Dalbis-Tran and Pascal Mermilloda
Expression regulated by
Comment
Ovarian localization Oocyte
Comment This gene was found in bovine oocyte by Dalbies-Tran R, Mermillod P. 2003 . The authors have analyzed gene expression in bovine oocytes before and after in vitro maturation (IVM) using heterologous hybridization onto cDNA array. Total RNA was purified from pools of over 200 oocytes either immediately after aspiration from follicles at the surface of slaughterhouse cow ovaries or following in vitro maturation. Radiolabeled cDNA probes were generated by reverse-transcription followed by linear PCR amplification and were hybridized to Atlas human cDNA arrays. To our knowledge, this is the first report of gene expression profiling by this technology in the mammalian female germ cell. Our results demonstrate that cDNA array screening is a suitable method for analyzing the transcription pattern in oocytes. About 300 identified genes were reproducibly shown to be expressed in the bovine oocyte, the largest profile available so far in this model. The relative abundance of most messenger RNAs appeared stable during IVM. However, 70 transcripts underwent a significant differential regulation (by a factor of at least two). Their potential role in the context of oocyte maturation is discussed. Together they constitute a molecular signature of the degree of oocyte cytoplasmic maturation achieved in vitro.
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
OMIM \ Animal Model
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created: Nov. 13, 2003, 12:27 p.m. by: hsueh   email:
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last update: July 26, 2006, 2:49 p.m. by: Alex    email:



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