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Ovarian Kaleidoscope Database (OKdb)

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Octopamine receptor OKDB#: 2296
 Symbols: Octopamine receptor Species: D. melanogaster
 Synonyms:  Locus:


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General Comment Lee HG, et al 2003 reported that Octopamine receptor OAMB is required for ovulation in Drosophila melanogaster. Octopamine is a major monoamine in invertebrates and affects many physiological processes ranging from energy metabolism to complex behaviors. Octopamine binds to receptors located on various cell types and activates distinct signal transduction pathways to produce these diverse effects. We previously identified one of the Drosophila octopamine receptors named OAMB that produces increases in cAMP and intracellular Ca(2+) upon ligand binding. It is expressed at high levels in the brain. To explore OAMB's physiological roles, we generated deletions in the OAMB locus. The resultant oamb mutants were viable without gross anatomical defects. The oamb females displayed normal courtship and copulation; however, they were impaired in ovulation with many mature eggs retained in their ovaries. RT-PCR, in situ hybridization, and expression of a reporter gene revealed that OAMB was also expressed in the thoracicoabdominal ganglion, the female reproductive system, and mature eggs in the ovary. Moreover, analysis of various alleles pinpointed the requirement for OAMB in the body, but not in the brain, for female fecundity. The novel expression pattern of OAMB and its genetic resource described in this study will help advance our understanding on how the neuromodulatory or endocrine system controls reproductive physiology and behavior.

General function Receptor
Comment
Cellular localization Plasma membrane
Comment
Ovarian function Ovulation
Comment
Expression regulated by
Comment
Ovarian localization Oocyte
Comment
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
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created: Nov. 21, 2003, 1:28 p.m. by: hsueh   email:
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last update: Nov. 21, 2003, 1:28 p.m. by: system    email:



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