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Ovarian Kaleidoscope Database (OKdb)

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TNFR SF23 decoy receptor; TNF receptor SF23 OKDB#: 2309
 Symbols: TNFR SF23 decoy receptor; TNF receptor SF23 Species: G. gallus
 Synonyms:  Locus:


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General Comment Alternatively Spliced Variants of Gallus gallus TNFRSF23 Are Expressed in the Ovary and Differentially Regulated by Cell Signaling PathwaysBridgham JT, et al . As a result of searching recently available chicken (ch) expressed sequence tag (EST) databases, a new Tumor Necrosis Factor Receptor Super Family (TNFRSF) member with similarity to the murine (m) TNFRSF23 decoy receptor (DcR) has been identified. However, by comparison to the mTNFRSF23, there exist at least two splice variants of chTNFRSF23, one of which includes an intracellular death domain (TNFRSF23.v1) characteristic of death receptors, and the other with a truncated cytoplasmic domain of a DcR (named TNFRSF23.v2). These two splice variants of chTNFRSF23 display differential patterns of mRNA expression across various hen tissues, with the highest levels observed within reproductive tissues. More specifically, TNFRSF23.v1 is most highly expressed in preovulatory follicle granulosa cells in the ovary, whereas TNFRSF23.v2 mRNA is found at highest levels in ovarian stromal tissue. Primary culture experiments with granulosa cells determined that expression of TNFRSF23.v1 mRNA was decreased by protein kinase A signaling and enhanced by transforming growth factor (TGF)alpha treatment. Interestingly, TGFbeta1 and signaling via protein kinase C also enhanced levels of TNFRSF23.v1 expression, but only in undifferentiated granulosa cells from prehierarchal follicles. Based upon patterns of mRNA expression and its endocrine/paracrine regulation, we predict that ovarian chTNFRSF23 represents a modulator of granulosa cell survival and/or differentiation. Finally, the characterization of these receptor variants is of considerable interest from an evolutionary perspective in that they provide additional evidence to support a continuing divergence of TNFRSF members throughout vertebrate evolution.

General function Receptor
Comment
Cellular localization Plasma membrane
Comment
Ovarian function Follicle atresia
Comment
Expression regulated by
Comment
Ovarian localization Granulosa, Stromal cells
Comment
Follicle stages Preovulatory
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
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created: Dec. 10, 2003, 1:07 p.m. by: hsueh   email:
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last update: Dec. 10, 2003, 1:07 p.m. by: system    email:



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