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Ovarian Kaleidoscope Database (OKdb)

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Tesmin OKDB#: 2310
 Symbols: Tesmin Species: mouse
 Synonyms:  Locus:


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General Comment Olesen C et al 2003 reported that tesmin transcription is regulated differently during male and female meiosis. Tesmin is a protein with homology to the metal-binding motif of the metallothionein protein family. Tesmin has been described as a testis-specific transcript, which starts to accumulate in 8-day-old mouse spermatocytes. Herein, a differential display comparing meiotic gene expression in embryonic ovaries and mature testes also revealed the presence of the Tesmin transcript in fetal ovaries as well as in fetal and adult heart. Time-course experiments showed that Tesmin was expressed in a characteristic development-related manner in fetal ovaries. Only a weak expression was observed at E12(1/2), the strongest signal was reached at E14(1/2), whereas the signal declined between E14(1/2) and E16(1/2). This transitional expression coincides with the early stages of the female meiotic prophase I. In the male, however, Tesmin was expressed in all stages of meiotic prophase I except preleptonema and leptonema. In situ hybridization further showed that the mRNA level increased during prophase I in the male, with the strongest expression seen at the transition from mid- to late pachytema (Stage VII-VIII). Furthermore, initiation of Tesmin transcription paralleled that of the synaptonemal complex protein 1 transcript (Scp1) in the fetal ovary and prepubertal testis. We, therefore, propose that Tesmin is likely to have a function in both the male and female meiotic prophase I. Moreover, the distinct difference in both the timing and the level of mRNA accumulation in the two gender's meiotic prophase I suggests that Tesmin transcription may be controlled by two different mechanisms during male and female meiosis.

General function
Comment
Cellular localization Nuclear
Comment
Ovarian function Oogenesis
Comment
Expression regulated by
Comment
Ovarian localization Oocyte
Comment
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
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created: Dec. 10, 2003, 1:14 p.m. by: hsueh   email:
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last update: Dec. 10, 2003, 1:14 p.m. by: system    email:



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