| Peptidyl-prolyl Isomerase D | OKDB#: 2340 |
| Symbols: | PPID | Species: | human | ||
| Synonyms: | CYCLOPHILIN D, CYPD|CYCLOPHILIN 40, CYP40| | Locus: | 4q31.3 in Homo sapiens |
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| General Comment |
The cyclophilins are a conserved gene family of peptidyl-prolyl cis-trans isomerases (PPIases; see 123840), the members of which bind the immunosuppressant cyclosporin A. Cyclophilin 40 (CyP-40, also CYPD) was identified by Kieffer et al. (1992) as a 40-kD cyclophilin-like protein with PPIase activity.
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| General function | Cell death/survival, Anti-apoptotic | ||||
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| Cellular localization | Mitochondrial | ||||
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| Ovarian function | Follicle atresia | ||||
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| Comment | Cyclophilin d, a component of the permeability transition-pore, is an apoptosis repressor. Schubert A, et al . The permeability transition (PT)-pore is an important proapoptotic protein complex in mitochondria. Although it is activated by many signals for apoptosis induction, the role of its various subunits in cell death induction has remained largely unknown. We found that of its components, only the voltage-dependent anion channel in the outer mitochondrial membrane and the adenine nucleotide translocator-1 (ANT-1), a PT-pore subunit of the inner membrane, are apoptosis inducers. We also report that ANT-1's direct interactor, cyclophilin D, can specifically repress ANT-1-induced apoptosis. In addition, cotransfection experiments revealed that for a diverse range of apoptosis inducers, cyclophilin D shows the same repression profile as the compound bongkrekic acid, a specific inhibitor of the PT-pore. This activity seems to be independent of its chaperone activity, the only known function of cyclophilin D to date. Importantly, cyclophilin D is specifically up-regulated in human tumors of the breast, ovary, and uterus, suggesting that inhibition of the PT-pore via up-regulation of cyclophilin D plays a role in tumorigenesis. | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | Jan. 22, 2004, 12:48 p.m. | by: |
hsueh email:
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| last update: | Jan. 22, 2004, 12:48 p.m. | by: | system email: |
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