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LECTIN, C-TYPE, SUPERFAMILY MEMBER 2; CLECSF2 OKDB#: 2343
 Symbols: LECTIN, C-TYPE, SUPERFAMILY MEMBER 2; CLECSF2 Species: ---
 Synonyms: ACTIVATION-INDUCED C-TYPE LECTIN, AICL|LECTIN, C-TYPE, ACTIVATION-INDUCED|  Locus: 12p13-p12 in Homo sapiens


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General Comment A C-type lectin associated and translocated with cortical granules during oocyte maturation and egg fertilization in fish Dong CH,et al . Oocyte maturation and egg fertilization in both vertebrates and invertebrates are marked by orchestrated cytoplasmic translocation of secretory vesicles known as cortical granules. It is thought that such redistribution of cellular content is critical for asymmetrical cell division during early development, but the mechanism and regulation of the process is poorly understood. Here we report the identification, purification and cDNA cloning of a C-type lectin from oocytes of a freshwater fish species gibel carp (Carassius auratus gibelio). The purified protein has been demonstrated to have lectin activity and to be a Ca(2+)-dependent C-type lectin by hemagglutination activity assay. Immunocytochemistry revealed that the lectin is associated with cortical granules, gradually translocated to the cell surface during oocyte maturation, and discharged to the egg envelope upon fertilization. Interestingly, the lectin becomes phosphorylated on threonine residues upon induction of exocytosis by fertilization and returns to its original state after morula stage of embryonic development, suggesting that this posttranslational modification may represent a critical molecular switch for early embryonic development.

NCBI Summary: This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell activation antigen. An alternative splice variant has been described but its full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.
General function Cell adhesion molecule
Comment
Cellular localization Plasma membrane
Comment
Ovarian function Oogenesis
Comment
Expression regulated by
Comment
Ovarian localization Oocyte
Comment
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
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created: Jan. 22, 2004, 2:43 p.m. by: hsueh   email:
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last update: Jan. 22, 2004, 2:43 p.m. by: system    email:



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