| Protein-tyrosine Phosphatase, Receptor-type, Gamma | OKDB#: 2421 |
| Symbols: | PTPRG | Species: | human | ||
| Synonyms: | PROTEIN-TYROSINE PHOSPHATASE GAMMA, PTPG | Locus: | 3p14.2 in Homo sapiens |
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| General Comment | NCBI Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. | ||||
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| Ovarian localization | Oocyte | ||||
| Comment | Bermudez MG, et al. (Reproductive BioMedicine Online 2004 8(3)) studied the gene expression profiling in human oocytes using cDNA microarray strategy and detected high expression of RPTPG. | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | March 18, 2004, 12:02 p.m. | by: |
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| last update: | March 18, 2004, 12:03 p.m. | by: | system email: |
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