| Suppressor Of Tumorigenicity 5 | OKDB#: 2434 |
| Symbols: | ST5 | Species: | human | ||
| Synonyms: | HELA TUMOR SUPPRESSION, HTS1 | Locus: | 11p15 in Homo sapiens |
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| General Comment | NCBI Summary: This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Two alternatively spliced transcript variants of this gene encoding distinct isoforms are reported. | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | April 7, 2004, 8:11 a.m. | by: |
hsueh email:
home page: |
| last update: | April 7, 2004, 8:11 a.m. | by: | system email: |
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