NCBI Summary:
This gene encodes a protein required for transactivation by the HIV-1 transactivator Tat. Although the encoded protein is not a TBP-associated factor (TAF), it is associated with the RNA polymerase II holoenzyme and is involved in the regulation of transcription elongation. This gene product has motifs found in transcription factors that permit protein-protein interactions, including a glutamine-alanine repeat not observed in mammalian transcription factors.
General function
Nucleic acid binding, DNA binding, Transcription factor
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Cellular localization
Nuclear
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Ovarian function
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Expression regulated by
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Ovarian localization
Oocyte
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Zheng P, et al compared the temporal expression patterns of five housekeeping mRNAs and three transcription factor mRNAs between mouse and rhesus monkey.