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Ovarian Kaleidoscope Database (OKdb)

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HPMR

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beta-2-microglobulin OKDB#: 2495
 Symbols: B2M Species: human
 Synonyms: IMD43  Locus: 15q21.1 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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DNA Microarrays
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link to BioGPS
General Comment The protein is a single polypeptide chain of molecular weight 11,600. Its complete amino acid sequence was reported by Cunningham et al. (1973). Although the function of beta-2-microglobulin is not known, the close homology in sequence to immunoglobulins suggests a common evolutionary origin. Beta-2-microglobulin also has structural relationships to HLA (being the low molecular weight component of the HLA antigens).

NCBI Summary: This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]
General function
Comment
Cellular localization Secreted
Comment
Ovarian function
Comment Selection of suitable reference genes for core clock gene expression analysis by real-time qPCR in rat ovary granulosa cells. Cai C et al. (2019) Selection of a suitable endogenous reference gene is essential for investigating expression of clock genes Bmal1, Clock, Pers, Crys, Rev-erbα/β, and RORα/β/γ involved in the circadian system. In this study, we treated rat ovary granulosa cells with dexamethasone to synchronize circadian oscillation in vitro and determined expression levels of Bmal1 and Per2 and six candidate reference genes (Actb, Beta actin; B2m, Beta-2-microglobulin; Ppia, Cyclophilin A; Gapdh, Glyceraldehyde-3-phosphate dehydrogenase; Hprt, Hypoxanthine guanine phosphoribosyl transferase and Tbp, TATA-box-binding protein) using quantitative real-time PCR. We then employed three software programs, GeNorm, NormFinder, and BestKeeper, to analyze the expression data for the selection of the best reference gene. According to GeNorm, Tbp and B2m were assessed as the most stable reference genes; Tbp and Hprt were best by NormFinder and BestKeeper, respectively. Thus, we recommend Tbp as the most suitable reference gene for studying clock genes expression in rat ovary granulosa cells in vitro.//////////////////
Expression regulated by
Comment
Ovarian localization
Comment This is a house-keeping gene found in a DNA microarray.
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
OMIM \ Animal Model
KEGG Pathways
Recent Publications
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created: June 18, 2004, 10:52 a.m. by: hsueh   email:
home page:
last update: April 30, 2019, 12:37 p.m. by: hsueh    email:



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