| Ephrin Receptor Epha8 | OKDB#: 2501 |
| Symbols: | EPHA8 | Species: | human | ||
| Synonyms: | EPH- AND ELK-RELATED KINASE, EEK|PROTEIN TYROSINE KINASE EEK|HEK3 | Locus: | 1 in Homo sapiens |
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| General Comment | NCBI Summary: This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. | ||||
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| Comment | This gene was identified to be expressed in the ovary through a series of mouse ovary microarray analyses. | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | June 18, 2004, 1:53 p.m. | by: |
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| last update: | May 28, 2005, 12:17 p.m. | by: | system email: |
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