| Ephrin Receptor Ephb6 | OKDB#: 2502 |
| Symbols: | EPHB6 | Species: | human | ||
| Synonyms: | HUMAN KINASE-DEFECTIVE Eph-FAMILY RECEPTOR PROTEIN, HEP | Locus: | 7q33-q35 in Homo sapiens |
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| General Comment | NCBI Summary: Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ephrin receptor encoded by this gene lacks the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands. | ||||
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| Ovarian localization | |||||
| Comment | This gene was identified to be expressed in the ovary through a series of mouse ovary microarray analyses. | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | June 18, 2004, 1:54 p.m. | by: |
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| last update: | June 18, 2004, 1:54 p.m. | by: | system email: |
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