| Anaplastic Lymphoma Kinase | OKDB#: 2528 |
| Symbols: | ALK | Species: | human | ||
| Synonyms: | Locus: | 2p23 in Homo sapiens | HPMR |
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| General Comment | NCBI Summary: The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK (leukocyte tyrosine kinase). ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. | ||||
| General function | Receptor, Enzyme | ||||
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| Cellular localization | Plasma membrane | ||||
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| Ovarian function | |||||
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| Expression regulated by | |||||
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| Ovarian localization | |||||
| Comment | This gene was found through a series of mouse ovary microarray analyese. | ||||
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| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | June 30, 2004, 8:54 a.m. | by: |
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| last update: | May 28, 2005, 12:13 p.m. | by: | system email: |
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