| Monogenic Audiogenic Seizure Susceptibility 1, Mouse, Homolog Of | OKDB#: 2542 |
| Symbols: | MASS1 | Species: | human | ||
| Synonyms: | VERY LARGE G PROTEIN-COUPLED RECEPTOR 1, VLGR1|KIAA0686 | Locus: | 5q14 in Homo sapiens | HPMR |
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R-L INTERACTIONS MGI |
| General Comment |
This gene is a GPCR. Calcium overlay binding analysis indicated that the extracellular repeat domains bind Ca(2+). The binding was not inhibited by magnesium, but it was inhibited by neomycin and by gadolinium. Western blot analysis showed expression of an approximately 220-kD cell surface VLGR1 protein. Nikkila et al. (2000) proposed that VLGR1 binds its ligand through calcium-mediated interactions.
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| General function | Receptor | ||||
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| Cellular localization | Plasma membrane | ||||
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| Expression regulated by | |||||
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| Ovarian localization | |||||
| Comment | This orphan receptor was found in a DNA array. | ||||
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| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | July 19, 2004, 10:52 a.m. | by: |
hsueh email:
home page: |
| last update: | July 19, 2004, 10:58 a.m. | by: | system email: |
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