| Latent Transforming Growth Factor-beta-binding Protein 4 | OKDB#: 2574 |
| Symbols: | LTBP4 | Species: | human | ||
| Synonyms: | LATENT TRANSFORMING GROWTH FACTOR-BETA-BINDING PROTEIN 4, SHORT, INCLUDED, LTBP4S, INCLUDED|LATENT TRANSFORMING GROWTH FACTOR-BETA-BINDING PROTEIN 4, LONG, INCLUDED, LTBP4L, INCLUDED | Locus: |
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| General Comment | NCBI Summary: Transforming growth factor-beta, or TGFB (see TGFB1; MIM 190180), remains biologically latent after secretion, blocked from activity by its N-terminal propeptide (the latency-associated peptide, or LAP). TGFB is activated by its dissociation from LAP. The latent form of TGFB is secreted in association with a latent TGFB-binding protein, or LTBP (see LTBP1; MIM 150390), and assembled into the extracellular matrix. LTBPs are mainly composed of epidermal growth factor (EGF; MIM 131530)-like repeats and protein domains with 8-cysteine repeats, both of which are also found in fibrillins (e.g., MIM 134797). See Oklu and Hesketh (2000) [PubMed 11104663] for a review of the LTBP gene family.[supplied by OMIM] | ||||
| General function | Extracellular binding protein | ||||
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| Cellular localization | Secreted | ||||
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| Ovarian function | |||||
| Comment | Found in an ovaulation array. | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | July 28, 2004, 1:52 p.m. | by: |
hsueh email:
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| last update: | July 28, 2004, 1:52 p.m. | by: | system email: |
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