TSC22 encodes a transcription factor and belongs to the large family of early response genes.
This gene was found to be regulated by gonadotropins in DNA arrays.
NCBI Summary:
This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
General function
DNA binding, Transcription factor
Comment
Cellular localization
Nuclear
Comment
Ovarian function
Comment
Found in an ovualtion array.
Expression regulated by
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Ovarian localization
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Follicle stages
Primordial
Comment
Arraztoa JA, et al 2005 reported the identification of genes expressed in primate primordial oocytes.