| S-adenosylmethionine Decarboxylase | OKDB#: 2634 |
| Symbols: | AMD1 | Species: | human | ||
| Synonyms: | AMD, SAM, SAMDC | Locus: | 6q21-q22 in Homo sapiens |
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For retrieval of Nucleotide and Amino Acid sequences please go to:
OMIM
Entrez Gene
Mammalian Reproductive Genetics Endometrium Database Resource Orthologous Genes UCSC Genome Browser GEO Profiles new! Amazonia (transcriptome data) new! R-L INTERACTIONS MGI |
| General Comment |
The biosynthesis of polyamines, which are universally essential for cellular functions, takes place from arginine and methionine and involves 4 distinct enzymes: spermidine synthase (EC 2.5.1.16), ornithine decarboxylase (165640), S-adenosyl-L-methionine decarboxylase (180980), and spermine synthase (300105).
NCBI Summary: The product of this gene is an important intermediate enzyme in polyamine biosynthesis. The polyamines spermine, spermidine, and putrescine are low-molecular-weight aliphatic amines essential for cellular proliferation and tumor promotion. This gene spans 22 kb comprised of 9 exons and 8 introns and encoding two species of mRNA of 2.1 and 3.4-3.6 kb originating from the use of two different polyadenylation signals. The pro-protein is an approximate 38.3 kDa which is known to undergo processing at amino acid 68 to yield two fragments of 32- and 6-kDa. |
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| General function | Enzyme | ||||
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| Cellular localization | Cytoplasmic | ||||
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| Ovarian function | |||||
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| Expression regulated by | |||||
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| Ovarian localization | |||||
| Comment | FOund in an ovarian cDNA library. | ||||
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| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | Oct. 24, 2004, 9:55 a.m. | by: |
hsueh email:
home page: |
| last update: | March 4, 2009, 2:43 p.m. | by: | hsueh email: |
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