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General Comment |
Using a subtractive cloning strategy to identify downstream targets of peroxisome proliferator-activated receptor-gamma (PPARG; 601487), and by screening cDNA libraries, Yoon et al. (2000) isolated mouse and human cDNAs encoding PGAR. The 406-amino acid, 60-kD human PGAR protein, which shares 75% amino acid identity with the mouse protein, is a member of the angiopoietin family of secreted proteins and bears highest similarity to angiopoietin-2 (ANGPT2; 601922).
NCBI Summary:
This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013]
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