| Nuclear Factor Kappa-b, Subunit 2 | OKDB#: 2709 |
| Symbols: | NFKB2 | Species: | human | ||
| Synonyms: | TRANSCRIPTION FACTOR NFKB2|NFKB, p52/p100 SUBUNIT|NUCLEAR FACTOR OF KAPPA LIGHT CHAIN GENE ENHANCER IN B CELLS 2|ONCOGENE LYT 10, LYT10|LYMPHOCYTE TRANSLOCATION CHROMOSOME 10 | Locus: | 10q24 in Homo sapiens |
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For retrieval of Nucleotide and Amino Acid sequences please go to:
OMIM
Entrez Gene
Mammalian Reproductive Genetics Endometrium Database Resource Orthologous Genes UCSC Genome Browser GEO Profiles new! Amazonia (transcriptome data) new! R-L INTERACTIONS MGI |
| General Comment | NCBI Summary: NFKB has been detected in numerous cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. NFKB is activated by a wide variety of stimuli such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NF-kappa-B has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. In contrast, complete and persistent inhibition of NF-kappa-B has been linked directly to apoptosis, inappropriate immune cell development, and delayed cell growth. For reviews, see Chen et al. (1999) [PubMed 9895331] and Baldwin (1996) [PubMed 8717528].[supplied by OMIM] | ||||
| General function | Cell death/survival, Nucleic acid binding, DNA binding, Transcription factor | ||||
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| Cellular localization | Nuclear | ||||
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| Ovarian function | |||||
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| Expression regulated by | |||||
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| Ovarian localization | |||||
| Comment | This gene was found in an ovulation array. | ||||
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| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | Jan. 25, 2005, 4:12 p.m. | by: |
hsueh email:
home page: |
| last update: | Jan. 25, 2005, 4:14 p.m. | by: | system email: |
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