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Ovarian Kaleidoscope Database (OKdb)

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daughterless OKDB#: 2716
 Symbols: da Species: D. melanogaster
 Synonyms:  Locus: 2 in Homo sapiens


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General Comment daughterless functions with Notch and Delta in ovarian follicle formation Cummings & Cronmiller (1994) . daughterless is required for somatic cell proliferation in the ovary, differentiation of interfollicular stalk cells, and a germline cyst progression checkpoint in the germarium. daughterless interacts genetically with genes belonging to the Epidermal Growth Factor Receptor (EGFR) pathway, the Janus Kinase/Signal Transduction and Activator of Transcription (JAK/STAT) pathway, as well as members of the Notch pathway. Smith et al (2002) . URL:http://www.flybase.org/.bin/fbidq.html?FBgn0000413

General function DNA binding, Transcription factor
Comment bHLH class I (E protein); TCF3 homolog (OKDB#:3681)
Cellular localization Nuclear
Comment Cronmiller & Cummings (1993)
Ovarian function Follicle development, Oogenesis
Comment
Expression regulated by
Comment
Ovarian localization
Comment somatic cells, interfollicular stalks Cummings & Cronmiller (1994)
Follicle stages
Comment
Phenotypes
Mutations 1 mutations

Species: D. melanogaster
Mutation name: da[lyh]
type: naturally occurring
fertility: infertile - ovarian defect
Comment: Springer retrotransposon insertion removes somatic ovary expression Smith & Cronmiller (2001)

Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
OMIM \ Animal Model
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created: Jan. 28, 2005, 10:19 a.m. by: DrJES3   email:
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last update: Feb. 7, 2006, 11:52 a.m. by: drjes3    email:



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