Stanford Home
Ovarian Kaleidoscope Database (OKdb)

Home

History

Transgenic Mouse Models

INFORGRAPHICS

Search
Submit
Update
Chroms
Browse
Admin

Hsueh lab

HPMR

Visits
since 01/2001:
176557

Tex101RP OKDB#: 2723
 Symbols: Tex101RP Species: human
 Synonyms:  Locus:


For retrieval of Nucleotide and Amino Acid sequences please go to:   UCSC Genome Browser   GEO Profiles new!   Amazonia (transcriptome data) new!
R-L INTERACTIONS   MGI

DNA Microarrays
SHOW DATA ...
link to BioGPS
General Comment Sexually Dimorphic Expression of the Novel Germ Cell Antigen TEX101 Reactive Protein During Mouse Gonad Development Takayama T, et al . Prospermatogonia or gonocytes are the cells that differentiation from primordial germ cells to the first mature type spermatogonia in the developing testis. Although prospermatogonia play a central role in this stage (i.e., prespermatogenesis) the details regarding their characterization have not been fully elucidated. Recently, we identified a novel mouse testicular germ cell-specific antigen, TES101 reactive protein (TES101RP), in the adult mouse testis. The protein TES101RP is also designated as protein TEX101. In the present study, we investigated the expression of TEX101 on germ cells in developing mouse gonads using histochemical techniques (i.e., immunohistochemistry, BrdU labeling, and TUNEL staining) and RT-PCR. TEX101 appeared on germ cells in both the male and female gonads after the pregonadal period. In the testis, TEX101 was expressed constitutively on surviving prospermatogonia during prespermatogenesis. After the initiation of spermatogenesis, the prospermatogonia differentiated into spermatogonia. TEX101 expression disappeared from the spermatogonia, but reappeared on spermatocytes and spermatids. In the ovary, TEX101 was expressed on germ cells until the start of folliculogenesis; TEX101 was not detected on oocytes that were surrounded by follicular cells. These findings indicate that TEX101 is a specific marker for both male and female germ cells during gonadal development. Since the switching on and off of TEX101 expression in germ cells almost parallels the kinetics of gametogenesis, TEX101 may play an important physiological role in germ cell development.

General function
Comment
Cellular localization
Comment
Ovarian function Germ cell development
Comment
Expression regulated by
Comment
Ovarian localization Primordial Germ Cell
Comment
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
Recent Publications
None
Search for Antibody


created: Feb. 9, 2005, 11:44 a.m. by: hsueh   email:
home page:
last update: Feb. 9, 2005, 11:44 a.m. by: system    email:



Use the back button of your browser to return to the Gene List.

Click here to return to gene search form