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zinc finger protein 106 homolog (mouse) OKDB#: 2762
 Symbols: ZFP106 Species: human
 Synonyms: SH3BP3, ZNF474,  Locus: 15q15.1 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: Entrez Gene
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General Comment
General function Nucleic acid binding, DNA binding, Transcription factor
Comment
Cellular localization Nuclear
Comment
Ovarian function
Comment
Expression regulated by
Comment
Ovarian localization
Comment Molecular cloning and character analysis of the mouse zinc finger protein gene Zfp474 exclusively expressed in testis and ovary] [Zhou C, et al . A novel mouse zinc finger protein gene that contains C2HC/C3H domain was first isolated by using a data-mining tool called Digital Differential Display (DDD) from the National Center for Biotechnology Information. The full-length cDNA of this transcript was deduced and further confirmed by reverse transcriptase polymerase chain reaction (RT-PCR). Total four exons of the mouse gene spaning a 29 869 bp genomic DNA sequence was mapped to chromosome 18D1. The cDNA encodes a novel protein of 347 amino acids and the protein contains four C2HC/C3H domains. Northern blot analyses revealed that Zfp474 mRNA was exclusively expressed in testis and ovary and had one transcript. We hypothesize that Zfp474 functions as a germ cell specific transcription factor that plays important roles in spermatid differentiation and oocyte development.
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
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created: March 16, 2005, 7:49 a.m. by: hsueh   email:
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last update: March 16, 2005, 7:51 a.m. by: system    email:



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