| zinc finger protein 106 homolog (mouse) | OKDB#: 2762 |
| Symbols: | ZFP106 | Species: | human | ||
| Synonyms: | SH3BP3, ZNF474, | Locus: | 15q15.1 in Homo sapiens |
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For retrieval of Nucleotide and Amino Acid sequences please go to:
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| General Comment | ||||
| General function | Nucleic acid binding, DNA binding, Transcription factor | |||
| Comment | ||||
| Cellular localization | Nuclear | |||
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| Ovarian function | ||||
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| Expression regulated by | ||||
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| Ovarian localization | ||||
| Comment | Molecular cloning and character analysis of the mouse zinc finger protein gene Zfp474 exclusively expressed in testis and ovary] [Zhou C, et al . A novel mouse zinc finger protein gene that contains C2HC/C3H domain was first isolated by using a data-mining tool called Digital Differential Display (DDD) from the National Center for Biotechnology Information. The full-length cDNA of this transcript was deduced and further confirmed by reverse transcriptase polymerase chain reaction (RT-PCR). Total four exons of the mouse gene spaning a 29 869 bp genomic DNA sequence was mapped to chromosome 18D1. The cDNA encodes a novel protein of 347 amino acids and the protein contains four C2HC/C3H domains. Northern blot analyses revealed that Zfp474 mRNA was exclusively expressed in testis and ovary and had one transcript. We hypothesize that Zfp474 functions as a germ cell specific transcription factor that plays important roles in spermatid differentiation and oocyte development. | |||
| Follicle stages | ||||
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| Phenotypes | ||||
| Mutations | 0 mutations | |||
| Genomic Region | show genomic region | |||
| Phenotypes and GWAS | show phenotypes and GWAS | |||
| Links |
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| created: | March 16, 2005, 7:49 a.m. | by: |
hsueh email:
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| last update: | March 16, 2005, 7:51 a.m. | by: | system email: |
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