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Ovarian Kaleidoscope Database (OKdb)

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Diacylglycerol Kinase, Alpha, 80-kd OKDB#: 2834
 Symbols: DGKA Species: human
 Synonyms: DIACYLGLYCEROL KINASE, ALPHA, DAGK1|DAGK, 80-KD|DGK-ALPHA  Locus: 12q13.3 in Homo sapiens


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General Comment
General function Intracellular signaling cascade
Comment
Cellular localization Cytoplasmic
Comment
Ovarian function
Comment
Expression regulated by
Comment
Ovarian localization Theca
Comment Toya M, et al reported gene expression, cellular localization, and enzymatic activity of diacylglycerol kinase isozymes in rat ovary and placenta. Female reproductive organs show remarkable cyclic changes in morphology and function in response to a combination of hormones. Evidence has accumulated suggesting that phosphoinositide turnover and the consequent diacylglycerol (DG) protein kinase C (PKC) pathway are intimately involved in these mechanisms. The present study has been performed to investigate the gene expression, cellular localization, and enzymatic activity of the DG kinase (DGK) isozymes that control the DG-PKC pathway. Gene expression for DGKalpha, -epsilon, -zeta, and -iota was detected in the ovary and placenta. Intense expression signals for DGKzeta and -alpha were observed in the theca cells and moderate signals in the interstitium and corpora lutea of the ovary. On the other hand, signals for DGKepsilon were seen more intensely in granulosa cells. The present study reveals distinct patterns of mRNA localization for DGK isozymes in the rat ovary and placenta, suggesting that each isozyme plays a unique role in distinct cell types in these organs.
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
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created: May 4, 2005, 2:02 p.m. by: hsueh   email:
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last update: May 4, 2005, 2:03 p.m. by: system    email:



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