Stanford Home
Ovarian Kaleidoscope Database (OKdb)

Home

History

Transgenic Mouse Models

INFORGRAPHICS

Search
Submit
Update
Chroms
Browse
Admin

Hsueh lab

HPMR

Visits
since 01/2001:
176557

Potassium Voltage-gated Channel, Shal-related Subfamily, Member 2 OKDB#: 2878
 Symbols: KCND2 Species: human
 Synonyms: Kv4.2|KIAA1044  Locus: 7q31 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM   UCSC Genome Browser   GEO Profiles new!   Amazonia (transcriptome data) new!
R-L INTERACTIONS   MGI

DNA Microarrays
SHOW DATA ...
link to BioGPS
General Comment
General function Channel/transport protein
Comment Voltage-dependent K(+) channel acts as sex steroid sensor in endocrine cells of the human ovary Kunz L, et al . Molecular targets of rapid non-genomic steroid actions are not well known compared to those of the classical transcription pathway, but ion channels have recently been identified to be steroid-sensitive. Especially, in the ovary, the very organ producing high amounts of sex steroids, their rapid actions are not well examined. We now identified a yet unknown target for sex steroids, a voltage-dependent K(+) channel (K(v)4.2) that contributes to a transient outward K(+) current (I(A)) in human granulosa cells (GCs). Sex steroid hormones at concentrations typical for the ovary (1 microM) blocked K(v)4.2 thereby attenuating I(A) by about 25% within seconds. We also found both K(v)4.2 (KCND2) mRNA and protein in endocrine cells of the human and rhesus macaque ovary, emphasizing the physiological relevance of this channel. Therefore, we propose a role as fast-responding steroid sensor for the K(v)4.2 channel. The direct regulation of K(+) channel activity by sex steroids might represent a yet unknown mechanism of rapid steroid action in close proximity to the site of steroid production in the primate ovary. Our data might also be important for K(v)4 channels in the brain and the cardiovascular system where rapid steroid effects are discussed in the context of prevention of cell death.
Cellular localization Plasma membrane
Comment
Ovarian function
Comment
Expression regulated by
Comment
Ovarian localization
Comment
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
OMIM \ Animal Model
KEGG Pathways
Recent Publications
None
Search for Antibody


created: July 4, 2005, 12:50 a.m. by: hsueh   email:
home page:
last update: July 4, 2005, 12:50 a.m. by: system    email:



Use the back button of your browser to return to the Gene List.

Click here to return to gene search form