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HPMR

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Poliovirus Receptor-like 3</title><base Target=_top></head><body Bgcolor=#ffffff Text=#000000 Link=# OKDB#: 2880
 Symbols: symbols Species: human
 Synonyms: PVRL3|POLIOVIRUS RECEPTOR-RELATED 3, PVRR3, PRR3|NECTIN 3  Locus: 3 in Homo sapiens
HPMR


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General Comment
General function Receptor, Cell adhesion molecule
Comment
Cellular localization Plasma membrane
Comment
Ovarian function
Comment
Expression regulated by
Comment
Ovarian localization Granulosa
Comment Expression of nectin-2 in mouse granulosa cells Kawagishi R, et al . OBJECTIVE:: The development and maturation of the ovarian follicles are characterized by structural changes that require components involved in cell-cell adhesion systems. Recently a novel group of cell adhesion molecules named nectins has been identified. The present study examined expression and cell-specific localization of nectins during mouse follicular development. STUDY DESIGN:: Expression of nectins in mouse ovary was investigated by immnuoblot analysis and immunohistochemistry. More precise localization was determined by electron microscopy. RESULTS:: Immunoblot analysis revealed expression of nectin-2 and nectin-3 but not nectin-1 in ovarian granulosa cells. Immunohistochemistry demonstrated expression of nectin-2 at cell-cell adhesion sites of granulosa cell layer in the primary and preantral follicles. Especially, intense immunoreactivity of nectin-2 accumulated around the zona pellucida. In antral follicles, the intensity of nectin-2 expression on granulosa cells was decreased. By electron microscopy nectin-2 was detected not only on thin extensions of granulosa cells penetrating the zona pellucida, but also on the attachment sites between thin extensions of granulosa cells and oocyte surface. CONCLUSION:: The restricted expression of nectin-2 in the granulosa cells of primary and preantral follicles might reflect some of the molecular changes in cell-cell adhesion during early follicular development.
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
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created: July 4, 2005, 12:56 a.m. by: hsueh   email:
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last update: Nov. 4, 2015, 1:20 p.m. by: hsueh    email:



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