| Stabilin 2 | OKDB#: 2903 |
| Symbols: | STAB2 | Species: | human | ||
| Synonyms: | FELL, FEX2, HARE, FEEL-2, FELE-2, FELL-2, STAB-2, DKFZp434E0321,HEPATIC HYALURONAN CLEARANCE RECEPTOR|FASCICLIN EGF-LIKE, LAMININ-TYPE EGF-LIKE, AND LINK DOMAIN-CONTAINING SCAVENGER RECEPTOR 2, FEEL2 | Locus: | 12q23.3 in Homo sapiens | HPMR |
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For retrieval of Nucleotide and Amino Acid sequences please go to:
OMIM
Entrez Gene
Mammalian Reproductive Genetics Endometrium Database Resource Orthologous Genes UCSC Genome Browser GEO Profiles new! Amazonia (transcriptome data) new! R-L INTERACTIONS MGI |
| General Comment | NCBI Summary: This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes. | ||||
| General function | Receptor | ||||
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| Cellular localization | Plasma membrane | ||||
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| Ovarian function | Cumulus expansion | ||||
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| Comment | Multiple signalling defects in the absence of RIP140 impair both cumulus expansion and follicle rupture Tullet JM, et al . The expression of this gene was increased in the KO mice. | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | Aug. 18, 2005, 10:37 a.m. | by: |
hsueh email:
home page: |
| last update: | Aug. 18, 2005, 10:37 a.m. | by: | system email: |
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