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HPMR

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Insulin Receptor-related Receptor OKDB#: 2926
 Symbols: INSRR Species: human
 Synonyms: IRR,IRR  Locus: 1q21-q23 in Homo sapiens
HPMR


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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General Comment
General function Receptor
Comment
Cellular localization Plasma membrane
Comment
Ovarian function Ovulation
Comment
Expression regulated by LH
Comment
Ovarian localization Theca
Comment Expression of the Insulin Receptor-Related Receptor (IRR) is Induced by the Preovulatory Surge of LH in Thecal-Interstitial Cells of the Rat Ovary Dissen GA, et al . The insulin receptor-related receptor (IRR) is a member of the insulin receptor family that, on its own, recognizes neither insulin nor any of the identified insulin-related peptides. In both the nervous system and peripheral tissues, IRR mRNA is detected in cells that also express trkA, the nerve growth factor (NGF) tyrosine kinase receptor. In the ovary, the trkA gene is transiently activated in thecal-interstitial cells of large antral follicles at the time of the preovulatory surge of gonadotropins. The present study shows that the IRR gene is expressed in the same ovarian compartment, that IRR mRNA content increases strikingly in these cells in the afternoon of the first proestrus, and that - as in the case of trkA mRNA - the increase is caused by gonadotropins. The IRR mRNA species primarily affected is that encoding the full-length receptor; its increased abundance was accompanied by a corresponding change in IRR protein content. An extensive molecular search using several approaches, including the screening of cDNA libraries and PCR amplification with degenerate primers, did not yield an IRR ligand. Phylogenetic analysis of 20 insulin-related sequences and 15 relaxin family peptides from selected vertebrates indicated that the mammalian genome is unlikely to contain an additional ligand expressed from a distinct gene that is closely related to the insulin family. While the functional nature of the relationship between IRR and trkA receptors is unknown, the remarkable temporal and spatial specificity of their coordinated expression in the ovary before ovulation suggest that they target a functionally related set of downstream events associated with the ovulatory process.
Follicle stages Antral, Preovulatory
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
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created: Oct. 5, 2005, 1:16 p.m. by: hsueh   email:
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last update: Oct. 5, 2005, 1:16 p.m. by: system    email:



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