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Hsueh lab

HPMR

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zinc finger protein 471 OKDB#: 2934
 Symbols: ZNF471 Species: human
 Synonyms: ERP1, Z1971, KIAA1396,  Locus: 19q13.43 in Homo sapiens


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General Comment
General function
Comment
Cellular localization
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Ovarian function
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Expression regulated by
Comment
Ovarian localization Oocyte
Comment A role for the anaphase-promoting complex inhibitor Emi2/XErp1, a homolog of early mitotic inhibitor 1, in cytostatic factor arrest of Xenopus eggs Tung JJ, et al . Unfertilized vertebrate eggs are arrested in metaphase of meiosis II with high cyclin B/Cdc2 activity to prevent parthenogenesis. Until fertilization, exit from metaphase is blocked by an activity called cytostatic factor (CSF), which stabilizes cyclin B by inhibiting the anaphase-promoting complex (APC) ubiquitin ligase. The APC inhibitor early mitotic inhibitor 1 (Emi1) was recently found to be required for maintenance of CSF arrest. We show here that exogenous Emi1 is unstable in CSF-arrested Xenopus eggs and is destroyed by the SCF(betaTrCP) ubiquitin ligase, suggesting that endogenous Emi1, an apparent 44-kDa protein, requires a stabilizing factor. However, anti-Emi1 antibodies crossreact with native Emi2/Erp1/FBXO43, a homolog of Emi1 and conserved APC inhibitor. Emi2 is stable in CSF-arrested eggs, is sufficient to prevent CSF release, and is rapidly degraded in a Polo-like kinase 1-dependent manner in response to calcium-mediated egg activation. These results identify Emi2 as a candidate CSF maintenance protein.
Follicle stages
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created: Oct. 25, 2005, 2:13 p.m. by: hsueh   email:
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last update: Oct. 25, 2005, 2:15 p.m. by: system    email:



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