| Low Density Lipoprotein Receptor-related Protein 4 | OKDB#: 3013 |
| Symbols: | LRP4 | Species: | human | ||
| Synonyms: | LRP10, MEGF7, KIAA0816,MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS 7, MEGF7 | Locus: | 11p11.2-p12 in Homo sapiens | HPMR |
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| General Comment | |||||
| General function | Receptor | ||||
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| Cellular localization | Plasma membrane | ||||
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| Ovarian function | |||||
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| Expression regulated by | |||||
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| Ovarian localization | Primordial Germ Cell, Oocyte | ||||
| Comment | Expression of low density lipoprotein receptor-related protein 4 (Lrp4) gene in the mouse germ cells Yamaguchi YL, et al . The low density lipoprotein receptor-related protein 4 gene (Lrp4) was identified by subtractive screening of cDNAs of the migratory primordial germ cells (PGCs) of E8.5-9.5 embryo and E3.5 blastocysts. Lrp4 is expressed in PGCs in the hindgut and the dorsal mesentery of E9.5 embryos, and in germ cells in the genital ridges of male and female E10.5-13.5 embryos. Lrp4 is also expressed in spermatogonia of the neonatal and adult testes and in the immature oocytes and follicular cells of the adult ovary. The absence of Lrp4 expression in the blastocyst, embryonic stem cells and embryonic germ cells suggests the Lrp4 is a molecular marker that distinguishes the germ cells from embryo-derived pluripotent stem cells. | ||||
| Follicle stages | |||||
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| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | Feb. 1, 2006, 6:41 a.m. | by: |
hsueh email:
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| last update: | Feb. 1, 2006, 6:42 a.m. | by: | hsueh email: |
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