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Ovarian Kaleidoscope Database (OKdb)

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TOHLH1, testis and ovary expressed basic helix-loop-helix OKDB#: 3036
 Symbols: Species: human
 Synonyms:  Locus:


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R-L INTERACTIONS   MGI

DNA Microarrays
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General Comment Tohlh1 is essential for spermatogonial differentiation. Ballow D et al. Spermatogonia are adult germline stem cells that can both self-renew and differentiate into spermatocytes. Little is known about factors necessary for spermatogonial differentiation. We identified a novel germ-cell-specific transcription factor that we named Tohlh1 (testis and ovary expressed basic helix-loop-helix (bHLH) transcription factor). In males, Tohlh1 is preferentially expressed in prespermatogonia and Type A spermatogonia. Loss of Tohlh1 causes infertility by disrupting spermatogonial differentiation into spermatocytes. Seven-day-old testes without Tohlh1 still express the testis-specific transcription factors Etv5, Taf4b, Zfp148, and Plzf, overexpress a novel Tohlh2 bHLH transcription factor, but lack LIM homeobox gene Lhx8 and show reduced expression of Ngn3. Tohlh1 represents the first testis-specific bHLH transcription factor that is essential for spermatogonial differentiation.

General function DNA binding, Transcription factor
Comment
Cellular localization Nuclear
Comment
Ovarian function
Comment
Expression regulated by
Comment
Ovarian localization
Comment
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
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created: March 29, 2006, 9:08 a.m. by: hsueh   email:
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last update: March 29, 2006, 9:08 a.m. by: hsueh    email:



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