| CD99 molecule | OKDB#: 3092 |
| Symbols: | CD99 | Species: | human | ||
| Synonyms: | MIC2, HBA71, MIC2X, MIC2Y, MSK5X,MIC2, MIC2X, MIC2Y,SURFACE ANTIGEN MIC2, MIC2, MIC2X|MONOCLONAL ANTIBODY 12E7|E2 ANTIGEN|MSK5X, INCLUDED | Locus: | Xp22.32 and Yp11.3 in Homo sapiens |
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For retrieval of Nucleotide and Amino Acid sequences please go to:
OMIM
Entrez Gene
Mammalian Reproductive Genetics Endometrium Database Resource Orthologous Genes UCSC Genome Browser GEO Profiles new! Amazonia (transcriptome data) new! R-L INTERACTIONS MGI |
| General Comment |
Pseudoautosomal region
NCBI Summary: The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. Cyclophilin A binds to CD99 and may act as a signaling regulator of CD99. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2013] |
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| General function | Cell adhesion molecule | ||||
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| Cellular localization | Plasma membrane | ||||
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| Ovarian localization | Cumulus | ||||
| Comment | The human cumulus-oocyte complex gene-expression profile. Assou S et al. BACKGROUND: The understanding of the mechanisms regulating human oocyte maturation is still rudimentary. We have identified transcripts differentially expressed between immature and mature oocytes and cumulus cells. | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | June 20, 2006, 10:35 a.m. | by: |
Alex email:
home page: |
| last update: | April 12, 2014, 2:09 p.m. | by: | Hsueh email: |
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