| Semaphorin 3a | OKDB#: 3114 |
| Symbols: | SEMA3A | Species: | human | ||
| Synonyms: | SemD, SEMA1, SEMAD, SEMAL, coll-1, Hsema-I, SEMAIII, sema III, Hsema-III,SEMAPHORIN III|SEMAPHORIN D, SEMAD|COLLAPSIN 1, COLL1 | Locus: | 7p12.1 in Homo sapiens |
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| General Comment | NCBI Summary: This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease. | ||||
| General function | Ligand | ||||
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| Cellular localization | Secreted | ||||
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| Ovarian localization | Cumulus | ||||
| Comment | The human cumulus-oocyte complex gene-expression profile. Assou S et al. BACKGROUND: The understanding of the mechanisms regulating human oocyte maturation is still rudimentary. We have identified transcripts differentially expressed between immature and mature oocytes and cumulus cells. | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | June 20, 2006, 11:37 a.m. | by: |
Alex email:
home page: |
| last update: | July 6, 2006, 3:58 p.m. | by: | hsueh email: |
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