| engrailed homeobox 2 | OKDB#: 3143 |
| Symbols: | EN2 | Species: | human | ||
| Synonyms: | Locus: | 7q36.3 in Homo sapiens |
|
For retrieval of Nucleotide and Amino Acid sequences please go to:
OMIM
Entrez Gene
Mammalian Reproductive Genetics Endometrium Database Resource Orthologous Genes UCSC Genome Browser GEO Profiles new! Amazonia (transcriptome data) new! R-L INTERACTIONS MGI |
| General Comment |
Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring, Nature 2021 this gene is downstream of YAP1 in skin.
NCBI Summary: Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008] |
||||
| General function | Transcription factor | ||||
| Comment | |||||
| Cellular localization | Nuclear | ||||
| Comment | |||||
| Ovarian function | |||||
| Comment | |||||
| Expression regulated by | |||||
| Comment | |||||
| Ovarian localization | Oocyte | ||||
| Comment | |||||
| Follicle stages | Primordial | ||||
| Comment | Arraztoa JA, et al 2005 reported the identification of genes expressed in primate primordial oocytes. | ||||
| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
|
| created: | June 21, 2006, 10:44 a.m. | by: |
alex email:
home page: |
| last update: | April 25, 2021, 4:50 p.m. | by: | hsueh email: |
Click here to return to gene search form