| Transporter, Atp-binding Cassette, Major Histocompatibility Complex, 1 | OKDB#: 3186 |
| Symbols: | TAP1 | Species: | human | ||
| Synonyms: | APT1, PSF1, ABC17, ABCB2, RING4, TAP1N, D6S114E, FLJ26666, TAP1*0102N,TRANSPORTER, ABC, MHC, 1|ATP-BINDING CASSETTE, SUBFAMILY B, MEMBER 2, ABCB2|ATP-BINDING CASSETTE TRANSPORTER, MAJOR HISTOCOMPATIBILITY COMPLEX, 1|ABC TRANSPORTER, MHC, 1|PEPTIDE TRANSPO | Locus: | 6p21.3 in Homo sapiens |
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Entrez Gene
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| General Comment | NCBI Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. | ||||
| General function | Channel/transport protein | ||||
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| Follicle stages | Primordial | ||||
| Comment | Arraztoa JA, et al 2005 reported the identification of genes expressed in primate primordial oocytes. | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | June 21, 2006, 12:44 p.m. | by: |
alex email:
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| last update: | June 21, 2006, 1:29 p.m. | by: | alex email: |
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