NCBI Summary:
BLOC1S1 is a component of the ubiquitously expressed BLOC1 multisubunit protein complex. BLOC1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules (Starcevic and Dell'Angelica, 2004).[supplied by OMIM]
General function
Comment
Cellular localization
centrome
Comment
Ovarian function
Oocyte maturation
Comment
Expression regulated by
Comment
Ovarian localization
Oocyte
Comment
SLX2 interacting with BLOS2 is differentially expressed during mouse oocyte meiotic maturation. Zhuang XJ 2014 et al.
Gametogenesis is a complex biological process of producing cells for sexual reproduction. Xlr super family members containing a conserved COR1 domain play essential roles in gametogenesis. In the present study, we identified that Slx2, a novel member of Xlr super family, is specifically expressed in the meiotic oocytes, which is demonstrated by western blotting and immunohistochemistry studies. In the first meiotic prophase, Slx2 is unevenly distributed in the nuclei of oocytes, during which phase Slx2 is partly co-localized with SYCP3 in synaptonemal complex and ?H2AX in the nucleus of oocytes. Interestingly, the localization of Slx2 was found to be switched into the cytoplasm of oocytes after prometaphase I during oocyte maturation. Furthermore, yeast 2-hybrid and coimmunoprecipitation studies demonstrated that Slx2 interacts with BLOS2 which is a novel centrosome-associated protein and co-localized with ?-tubulin, which is a protein marker of chromosome segregation in meiosis. These results indicated that SLX2 might get involved in chromosomes segregation during meiosis by interaction with BLOS2. In conclusion, Slx2 might be a novel gametogenesis-related protein that could play multiple roles in regulation of meiotic processes including synaptonemal complex assembly and chromosome segregation.
/////////////////////////
Follicle stages
Primordial
Comment
Arraztoa JA, et al 2005 reported the identification of genes expressed in primate primordial oocytes.