| Nonmetastatic Cells 1, Protein Expressed In | OKDB#: 3207 |
| Symbols: | NME1 | Species: | human | ||
| Synonyms: | AWD, GAAD, NM23, NDPKA, NM23-H1,METASTASIS INHIBITION FACTOR NM23|NONMETASTATIC PROTEIN 23, NM23|NONMETASTATIC PROTEIN 23, HOMOLOG 1, NM23H1|NUCLEOSIDE DIPHOSPHATE KINASE-A, NDPKA|GZMA-ACTIVATED DNase, GAAD|AWD, DROSOPHILA, HOMOLOG OF, AWD|NM23H1B, INCLUD | Locus: | 17q21.3 in Homo sapiens |
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| General Comment | NCBI Summary: This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. | ||||
| General function | Cell death/survival, Apoptosis, Cell cycle regulation | ||||
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| Cellular localization | Cytoplasmic, Nuclear | ||||
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| Ovarian function | Oogenesis, Oocyte maturation | ||||
| Comment | Gene whose expression is detected by cDNA array hybridization: oncogenes, tumor suppressors, cell cycle regulators Rozenn Dalbi?Tran and Pascal Mermilloda | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | June 22, 2006, 10:03 a.m. | by: |
alex email:
home page: |
| last update: | July 25, 2006, 12:01 p.m. | by: | Alex email: |
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