| Mitogen-activated Protein Kinase Kinase 6 | OKDB#: 3241 |
| Symbols: | MAP2K6 | Species: | human | ||
| Synonyms: | MEK6, MKK6, MAPKK6, PRKMK6, SAPKK3,PROTEIN KINASE, MITOGEN-ACTIVATED, KINASE 6, PRKMK6|MKK6, MAPKK6|MAPK/ERK KINASE 6, MEK6 | Locus: | 17q24.3 in Homo sapiens |
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| General Comment |
NCBI Summary: This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. |
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| General function | Enzyme, Transferase | ||||
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| Ovarian function | Oogenesis, Oocyte maturation | ||||
| Comment | Genes whose expression is detected by cDNA array hybridization: transporters, signal transduction Rozenn Dalbis-Tran and Pascal Mermilloda | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | June 22, 2006, 11:45 a.m. | by: |
alex email:
home page: |
| last update: | July 25, 2006, 3:50 p.m. | by: | Alex email: |
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