| P21-activated Kinase 3 | OKDB#: 3248 |
| Symbols: | PAK3 | Species: | human | ||
| Synonyms: | bPAK, MRX30, MRX47, OPHN3, hPAK3, CDKN1A, PAK3beta,OLIGOPHRENIN 3, OPHN3 | Locus: | Xq22.3-q23 in Homo sapiens |
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| General Comment | NCBI Summary: PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. A point mutation in this gene has been linked to nonsyndromic X-linked mental retardation. | ||||
| General function | Enzyme, Transferase | ||||
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| Ovarian function | Oogenesis, Oocyte maturation | ||||
| Comment | Genes whose expression is detected by cDNA array hybridization: transporters, signal transduction Rozenn Dalbis-Tran and Pascal Mermilloda | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | June 22, 2006, 12:53 p.m. | by: |
alex email:
home page: |
| last update: | July 26, 2006, 10:16 a.m. | by: | Alex email: |
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