NCBI Summary:
The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008]
General function
Cell death/survival, Anti-apoptotic
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Cellular localization
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Ovarian function
Oogenesis, Oocyte maturation
Comment
Levels of CD40L and other inflammatory biomarkers in obese and non-obese women with polycystic ovary syndrome. Sarray S et al. (2016) We investigated whether changes in sCD40L, hs-CRP, IL-6, and TNF-α levels are associated with polycystic ovary syndrome (PCOS). Case-control study involving 143 women with and 165 women without PCOS. Reduced sCD40L, and increased hs-CRP and IL-6, but not TNF-α, levels were seen between cases and controls. ROC analysis demonstrated high sensitivity and specificity for sCD40L and hs-CRP as PCOS predictors. Altered sCD40L levels were associated with PCOS, irrespective of body weight. Significant differences in IL-6 levels were seen between non-obese subjects and for TNF-α in obese subjects. sCD40L correlated negatively with age, insulin, HOMA-IR, LH, free testosterone, FAI, and hirsutism, but positively with SHBG. CRP correlated positively with BMI, insulin, HOMA-IR, free testosterone, and hirsutism. IL-6 correlated positively with hirsutism. TNF-α correlated positively with age, but negatively with insulin and HOMA-IR. CD40L, more than IL-6, or TNF-α, constitutes a predictor to explain PCOS and associated features.//////////////////
Expression regulated by
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Ovarian localization
Comment
Polycystic ovary syndrome is associated with elevated plasma soluble CD40 ligand, a marker of coronary artery disease. Oktem M et al. OBJECTIVE: To determine the level of plasma soluble CD40 ligand (sCD40L) in patients with polycystic ovary syndrome (PCOS). DESIGN: Prospective study. SETTING: Baskent University School of Medicine in Turkey. PATIENT(S): Thirty-one patients with PCOS and 31 non-PCOS (control) patients. INTERVENTION(S): Determination of plasma sCD40L and homocysteine levels. MAIN OUTCOME MEASURE(S): Plasma sCD40L, fasting glucose, fasting insulin, homeostatic model assessment insulin resistance index (HOMA-IR), LH, FSH, E(2), total T, DHEAS, total cholesterol, high- and low-density lipoprotein cholesterol, triglyceride, homocysteine, and high-sensitivity C-reactive protein (hsCRP). RESULT(S): The mean serum fasting insulin and HOMA-IR levels were significantly higher in the PCOS group. The mean serum homocysteine level was significantly higher in the PCOS group. Despite a trend for higher high-sensitivity C-reactive protein levels in the PCOS group, the difference did not reach statistical significance. The mean plasma sCD40L level in the PCOS group was significantly higher than that in the control group (5.14 +/- 3.65 ng/mL vs. 3.45 +/- 2.64 ng/mL, respectively). CONCLUSION(S): Polycystic ovary syndrome is associated with elevated levels of sCD40L and homocysteine.