| Caspase 10, Apoptosis-related Cysteine Protease | OKDB#: 3267 |
| Symbols: | CASP10 | Species: | human | ||
| Synonyms: | MCH4, ALPS2, FLICE2,MCH4|CASPASE 10, ISOFORM B, INCLUDED, CASP10B, INCLUDED|FADD-LIKE ICE 2, INCLUDED, FLICE2, INCLUDED | Locus: | 2q33-q34 in Homo sapiens |
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Entrez Gene
Mammalian Reproductive Genetics Endometrium Database Resource Orthologous Genes UCSC Genome Browser GEO Profiles new! Amazonia (transcriptome data) new! R-L INTERACTIONS MGI |
| General Comment | NCBI Summary: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene. | ||||
| General function | Cell death/survival, Apoptosis | ||||
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| Ovarian function | Oogenesis, Oocyte maturation | ||||
| Comment | Gene whose expression is detected by cDNA array hybridization: GDP/GTP exchangers, GTPase stimulators and inhibitors, apoptosis Rozenn Dalbis-Tran and Pascal Mermilloda | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
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| created: | June 22, 2006, 2:19 p.m. | by: |
alex email:
home page: |
| last update: | July 26, 2006, 11:29 a.m. | by: | Alex email: |
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